Nexito 5mg Tablet 10pcs

Uses of Nexito 5mg Tablet

• Generalized anxiety disorder
• Depression

How does Nexito 5mg Tablet work?

It works by increasing the amount of a natural substance (serotonin) in your brain that helps maintain mental balance. 

Side Effects of Nexito 5mg Tablet

SSRIs generally cause fewer sedative and antimuscarinic effects compared to tricyclic antidepressants. Common side effects include gastrointestinal issues (nausea, vomiting, dyspepsia, abdominal pain, diarrhea, constipation), anorexia, weight loss, or weight gain. Other potential side effects include hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders, and visual disturbances.

Quick Suggestions:

• Take Nexito 5 Tablet with or without food. 
• Do not take in larger amounts than prescribed. 
• Consult your doctor if you experience any undesirable effects. 
• Do not stop taking the medicine without consulting your doctor as it may cause withdrawal symptoms.
• It has a lower chance of causing sexual dysfunction than other similar medications.
• The addiction or dependence potential of the Nexito 5 Tablet is very low.

Nexito is indicated for the:

• Treatment of major depressive episodes
• Treatment of panic disorder with or without agoraphobia
• Treatment of social anxiety disorder (social phobia)
• Treatment of generalized anxiety disorder
• Treatment of obsessive-compulsive disorder

Pharmacology

Escitalopram is an orally administered selective serotonin reuptake inhibitor (SSRI). It is the S-enantiomer of the racemic compound citalopram, making it significantly more potent in inhibiting serotonin reuptake than the R-enantiomer. Escitalopram has minimal or no affinity for various other receptors, including alpha- and beta-adrenergic, dopamine, histamine, muscarinic, and benzodiazepine receptors.

Dosage & Administration of Nexito 5mg Tablet

• Major depressive episodes: The typical dose is 10 mg once daily. Depending on the patient's response, the dose may be increased to a maximum of 20 mg daily. It usually takes 2-4 weeks to see an antidepressant effect. Treatment should continue for at least 6 months to consolidate the response.
• Panic disorder with or without agoraphobia: Start with 5 mg daily for the first week, then increase to 10 mg daily. The dose can be increased to a maximum of 20 mg daily based on the patient’s response. Maximum effectiveness is usually reached after about 3 months. Treatment lasts several months.
• Social anxiety disorder: The typical dose is 10 mg once daily. It usually takes 2-4 weeks to relieve symptoms. Depending on the response, the dose may be adjusted to 5 mg or increased to a maximum of 20 mg daily. Treatment for 12 weeks is recommended to consolidate the response, and long-term treatment (up to 6 months) can be considered on an individual basis.
• Generalized anxiety disorder: Start with 10 mg once daily, which can be increased to a maximum of 20 mg daily depending on the patient's response. Long-term treatment has been studied for at least 6 months in patients taking 20 mg/day. Treatment benefits and dose should be re-evaluated regularly.
• Obsessive-Compulsive Disorder: Start with 10 mg once daily, which can be increased to a maximum of 20 mg daily based on the patient's response. As OCD is chronic, patients should be treated long enough to ensure they are symptom-free. Treatment benefits and dose should be re-evaluated regularly.

Daily doses above 20 mg have not been proven safe. Escitalopram Oxalate should be taken as a single daily dose, with or without food. Escitalopram should be taken once daily, either in the morning or evening, with or without food.

• Elderly patients (>65 years): Start with 5 mg once daily, which can be increased to 10 mg daily based on response.
• Children and adolescents (<18 years): Nexito is not recommended for this age group.
• Reduced renal function: No dosage adjustment is needed for mild to moderate renal impairment, but caution is advised for severe renal impairment (CLCR <30 ml/min).
• Reduced hepatic function: Start with 5 mg daily for the first two weeks, increasing to 10 mg daily based on response. Caution and careful dose titration are needed for severe hepatic impairment.
• Poor metabolizers of CYP2C19: Start with 5 mg daily for the first two weeks, increasing to 10 mg daily based on response.

Interaction

SSRIs or related antidepressants should not be started until 2 weeks after stopping an MAOI. Conversely, an MAOI should not be started until at least a week after stopping an SSRI or related antidepressant (2 weeks for paroxetine and sertraline, at least 5 weeks for fluoxetine).

Contraindications

Escitalopram is contraindicated in patients with known hypersensitivity to escitalopram, citalopram, or any inactive ingredients in the drug. It should not be used in patients taking monoamine oxidase inhibitors (MAOIs) or pimozide.

Pregnancy & Lactation

When treating pregnant women with escitalopram during the third trimester, the physician should carefully consider the potential risks and benefits. Escitalopram is excreted in human breast milk, and the decision to continue or discontinue either nursing or escitalopram therapy should consider the risk to the infant and the benefit to the mother.

Precautions & Warnings

SSRIs should be used cautiously in patients with epilepsy, poorly controlled epilepsy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concurrent electroconvulsive therapy, and patients at risk of bleeding. They should also be used with caution in patients with hepatic and renal impairment.

When stopping treatment, the dose should be gradually reduced over at least 1-2 weeks to minimize withdrawal symptoms. If intolerable symptoms occur, the previously prescribed dose may be resumed before tapering off more gradually.

Storage Conditions:

Store below 30°C, protected from light and moisture. Keep out of reach of children.